The phrase "large spread" means a big difference or distance between two things.
Sentences with «large spread»
At firms with large spreads in partner compensation levels (that is to say, virtually all of them), junior partners are effectively being leveraged like associates. (law21.ca)
Just like regular stocks, thinly traded ETF's often have quite large spreads between buy and sell: in the 1.5 - 2 % + range in some cases. (money.stackexchange.com)
Since these games go under the majority of the time, favorites don't score as many points and have a tougher time covering large spreads. (sportsinsights.com)